Diterpenoid isolated from the bark of the yew tree (Taxus brevifolia).
Antitumor and antileukemic agent. Promotes the assembly of stable microtubules
and inhibits the disassembly process of microtubules to tubulin. Inhibits DNA
synthesis and stimulates the release of TNFα
Assay (HPLC, TLC)
min. 97 %
Protect from light and moisture.
References:
Wani, M.C. et al. (1971) Am. Chem. Soc. 93, 2325
Manfredi, J.J. a. Horwitz, S.B. (1984) Pharmacol. Ther. 25, 83-125
Donaldson, K.L. et al. (1994) Int. J. Cancer 57, 847
Mitsuuchi, Y. et al. (2000) Cancer Res. 60, 5390-4
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H341
Deutsch:
Kann vermutlich genetische Defekte verursachen <Expositionsweg angeben, sofern schlüssig belegt ist, dass diese Gefahr bei keinem anderen Expositionsweg besteht>.
English:
Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
Français:
Susceptible d'induire des anomalies génétiques <indiquer la voie d'exposition s'il est formellement prouvé qu'aucune autre voie d'exposition ne conduit au même danger>.
Italiano:
Sospettato di provocare alterazioni genetiche <indicare la via di esposizione se è accertato che nessun'altra via di esposizione comporta il medesimo pericolo>.
Español:
Se sospecha que provoca defectos genéticos <Indíquese la vía de exposición si se ha demostrado concluyentemente que el peligro no se produce por ninguna otra vía >.
