General References

Elworthy, P.H. et al. (1968) Solubilization by surface-active agents and its application in chemistry and the biological sciences. Chapman and Hall Ltd., Great Britain.

Helenius, A. & Simons, K. (1975) Solubilization of membranes by detergents. Biochim. Biophys. Acta 415, 29-79.

Tanford,C. & Reynolds, J.A. (1976) Characterization of membrane proteins in detergent solutions. Biochim. Biophys. Acta 457, 133-170.

Helenius, A. et al. (1979) Properties of detergents. Methods Enzymol. LVI, 734-749.

Davis, A. (1984) Determination of the hydrodynamic properties of detergent-solubilized proteins. In: Molecular and chemical characterization of membrane receptors, p. 161-178. A.R. Liss Inc., New York.

Furth, A.H. et al. (1984) Separating detergents from proteins. Methods Enzymol. 104, 318-328.

Hjelmeland, L.M & Chrambach, A. (1984) Solubilization of functional membrane proteins. Methods Enzymol. 104, 303-318.

Hjelmeland, L.M. (1986) The design and synthesis of detergents for membrane biochemistry. Methods Enzymol. 124, 135-164.

Pfüller, U. (1986) Mizellen – Vesikel – Mikroemulsionen. Tensidassoziate und ihre Anwendung in Analytik und Biochemie. Springer-Verlag, Berlin, Heidelberg, New York, London, Paris, Tokyo.

Jones, O.T. et al. (1987) Solubilization and reconstitution of membrane proteins. In: Findlay, J.B.C. a. Evans, W.H. (eds.) Biological membranes – a practical approach, p. 139-177. IRL Press, Oxford.

Hjelmeland, L.M. (1990) Solubilization of native membrane Proteins. Methods Enzymol. 182, 253-64.

Fiona, A.O. et al. (1990) Solubilization of protein aggregates. Methods. Enzymol. 182, 264-76.

Hjelmeland, L.M. (1990) Removal of detergents from membrane proteins. Methods Enzymol. 182, 277-82.

Neugebauer, J.M. (1990) Detergents: an overview. Methods Enzymol. 182, 239-253.

Jones, M.N. (1999) Surfactants in membrane solubilisation. Int. J. Pharmaceutics 177, 137-59.

Ohlendieck, K. (2004) Extraction of membrane proteins, in: Methods in Molecular Biology, vol. 244: Protein Purification Protocols, 2nd ed., p. 283-93; Paul Cutler, editor, Humana Press.


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ImmunoPrecipitation (IP) is widely used as a method to selectively isolate protein complexes from primary tissues. However, due to lack of specificity and selectivity of most antibodies and unspecific binding of the carrier beads, the method can produce false positives. The ICPL approach, employing stable isotope labelling and mass spectrometry, can discriminate true positive from false positive IP complexes.

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