Mixture of homologuous nucleoside antibiotics. Consists of one residue each of
uracil, a C11-aminodeoxy- dialdose (tunicamine), N-acetyl
glucosamine and a fatty acid. The various tunicamycins differ from each other
in the chain length of their fatty acid component. Our preparation contains
mainly isomers A, B, C, and D whose fatty acid component contain 15, 16, 17,
and 18 C-atoms, respectively. Tunicamycin is active against Gram-positive
bacteria, yeast, fungi, and viruses. Inhibits N-linked glycosilation and
blocks the formation of N-glycosidic protein carbohydrate linkage; inhibits
the first step in the lipid-linked saccharide pathway, i.e. the formation of
dolichylpyrophosphoryl-GlcNAc. Soluble in DMF and DMSO. Protect from
light. Keep under argon.
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Kann die Organe schädigen <alle betroffenen Organe nennen, sofern bekannt> bei längerer oder wiederholter Exposition <Expositionsweg angeben, wenn schlüssig belegt ist, dass diese Gefahr bei keinem anderen Expositionsweg besteht>.
English:
May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
Français:
Risque présumé d'effets graves pour les organes <ou indiquer tous les organes affectés, s'ils sont connus> à la suite d'expositions répétées ou d'une exposition prolongée <indiquer la voie d'exposition s'il est formellement prouvé qu'aucune autre voie d'exposition ne conduit au même danger>.
Italiano:
Può provocare danni agli organi <o indicare tutti gli organi interessati, se noti> in caso di esposizione prolungata o ripetuta <indicare la via di esposizione se è accertato che nessun'altra via di esposizione comporta il medesimo pericolo>.
Español:
Puede provocar daños en los órganos <indíquense todos los órganos afectados, si se conocen> tras exposiciones prolongadas o repetidas <indíquese la vía de exposición si se ha demostrado concluyentemente que el peligro no se produce por ninguna otra vía>.
