Ion Exchangers

SERVA Ion Exchange Media and Adsorber Resins

Ion exchangers are usually solid, macromolecular polyelectrolytes in the form of macroscopic particles with a porous structure. They are insoluble in water but capable of swelling. They are able to exchange bound ions against others dissolved in the surrounding medium. The cation exchangers (polyacids) carry fixed negatively charged functional groups (anchor groups grafted onto the polymer) with positive counter-ions, while the anion exchangers (polybases) have positively charged groups fixed onto the polymer with negative counter-ions to equalize the charge. Binding and release of the counter-ions are reversible processes and dependent on their concentration and affinity to the anchor groups.

There are inorganic ion exchangers which are natural aluminium silicates, e.g. Zeolites, which are used for water softening and desalting or Bentonite, which can be used for detoxification and as an adsorbent for proteins and viruses. Furthermore there are synthetic organic ion exchange resins, which are mainly produced by polymerization. They are of fundamental importance for many industrial applications and described below in more detail.

Ion exchangers on the basis of modified agarose, cellulose or dextran are used for the separation of large biomolecules, e.g. proteins or nucleic acids (see SERVACEL® Cellulose Ion Exchangers).

Adsorber resins have a similar basic matrix as ion exchange resins, but without functional groups. Binding of substances runs via non-ionic forces (see SERDOLIT®  PAD Resins).

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Product of the Month September:

Xpress Micro and Mini Dialyzer

SERVA BlueNews 6/2016

New Application Note:
ICPL™ - Coupled Immunoprecipitation
(ICPL-IP)

New SERVA Brochures:
All you need for ...

The SERVA Catalog 2015/16:

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Product of the Month September:

Xpress Micro and Mini Dialyzer

Ready-to-use devices for fast and efficient dialysis of proteins, DNA and RNA samples ranging from 10 to 1000 µl

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SERVA BlueNews 6/2016

Please find the latest information
on new products and services here:

• 1D SDS TA Gels
• EPO Doping Analytics
• DNADecon
• New Tools in Dialysis
• Product of the Month
• Western Blot Workflow
• Sample Preparation by Protein Ark
• LED Gel Scanner BIO-1000F
• Collagenase AF GMP Grade
• Top Ten YouTube Videos

BlueNews: Issue June 2016.pdf
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New Application Note:
ICPL™ - Coupled Immunoprecipitation
(ICPL-IP)

ImmunoPrecipitation (IP) is widely used as a method to selectively isolate protein complexes from primary tissues. However, due to lack of specificity and selectivity of most antibodies and unspecific binding of the carrier beads, the method can produce false positives. The ICPL approach, employing stable isotope labelling and mass spectrometry, can discriminate true positive from false positive IP complexes.

SERVA ICPL™ Quadruplex Plus Kit 39233
Application Note: ICPL-IP
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The SERVA Catalog 2015/16:

• Biochemicals A-Z

• Sample Preparation

• Electrophoresis

• Laboratory Equipmeng

• Collagenase & Neutral Protease

• Life Sciences

• Enzymology

• Microscopy

• Ion Exchange Media

• Pharmacopoeia

Find the SERVA Online Catalog 2015/16 here!

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