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Sample Preparation

Purification of Biomolecules

Electrophoresis

From Sample to Separation

Laboratory Equipment

To run Your Experiments

Collagenase & Neutral Protease

For Tissue Dissociation
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Life Sciences

From Cells to Molecules

Enzymology

Enzymes, Substrates, Inhibitors, Detection

Microscopy

Fixation, Embedding, Staining

Ion Exchange Media

For Bioseparation Product Center

Pharmacopoeia Grade  

Partner Catalogs
Hoefer Inc., USA

Equipment for Electrophoresis

BioDrop

Micro-Volume Measurement

Elchrom Scientific, CH

Equipment & Gels for DNA Electrophoresis

BioCision, USA

Standardizing Samples

Isogen Life Science B.V.

Proxima Imaging Platform

Generon Ltd., UK

GST-tagged Protein Purification

Pro-Chem Inc., USA

Antibody Purification

 

HomeFeatured Products Life Sciences

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The BioDrop Family for micro-volume measurement

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Whatever your application — you can rely on the BioDrop range of instruments for rapid, simple and accurate measurement of your DNA, RNA, oligos and protein concentration and purity. BioDrop's fresh new approach has resulted in a range that is flexible when you require it, fast when you need it, and easy-to-use in every case.
The built-in sample port uses no moving parts. This meams that the instrument provides excellent reproducibility without the need to recondition or calibrate. Measurements are also highly accurate because the pathlength of the port is highly specified to +/- 5 µm.

Accuracy, robustness and ease of use are the hallmarks of BioDrop products.

BioDrop µLITE – The choice for life scientists for whom speed and accuracy in micro-volume measurement are required, rather than a broad measurement range
BioDrop DUO – The ideal solution for those where flexibility of measurement is the key
BioDrop TOUCH – A UV/VIS spectrophotometer ideal for use with BioDrop CUVETTEs
BioDrop CUVETTE – The revolutionary micro-volume device is an accurate and robust tool for measurement of DNA, RNA, oligos and protein. For the use with BioDrop DUO and BioDrop TOUCH as well as for all UV/VIS spectrophotometers with beam heights of 8.5 mm and 15 mm.
BioDrop Resolution Life Science PC Software – A powerful analysis software that is included with all instruments

BioDrop UV/VIS Spectrophotometer
BioDrop CUVETTE

SERVA Collagenase AF-1 GMP Grade &
SERVA Neutral Protease AF GMP Grade

Our most advanced enzymes - entirely free of animal-derived components

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Xenofrei – derived from C. histolyticum grown in a plant-based medium  
The sophisticated production process ensures no cross-contamination with any animal-based components  
Concerns regarding the introduction of animal-derived pathogens are eliminated and therefore regulatory hurdles are lowered  
Highly purified collagenase with high collagenolytic activity and diminished proteolytic side activities  
Necessary side activities can be achieved by adding purified neutral protease  
Higher enzyme stability and precise dosage for isolation of especially sensitive cells
Produced according to pharmaceutical manufacturing standards by Nordmark Arzneimittel GmbH & CoKG
Very low endotoxin levels and thorough microbial analysis
Excellent lot-to-lot consistency
→  Superior enzymes most suitable for clinical isolation and transplantation of cells 
17457 Collagenase AF-1 GMP Grade
30306 Neutral Protease AF GMP Grade

Collagen CS Solution 0.5 % in 0.01 M HCl

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Purified native collagen type I solution from bovine calf dermis. It has been acid solubilized without enzyme treatment and pepsin extraction.

  • Stronger gels with transparent to white appearance compared to pepsin solubilized collagen
  • Excellent substrate for coating of surfaces or use as a solid gel for improved attachment of thin layers of cells
  • Suitable for formation of an in vivo-like 3D matrix of collagen attached to the bottom of a culture dish
  • Can be used to build a floating pad in/on culture media for cell growth, cell migration assays, cell interaction
47257 Collagen CS solution 0.5 %

BioCision ThawSTAR™

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Standardize your cell thawing with ThawSTAR™ automated thawing system.
Replacing inadequate methods of cell thawing that are subject to contamination and have subjective end points - such as swirling frozen vials in communal water baths or warming them between hands - ThawSTAR™ enables rapid, consistent and reproducible thawing. Simply insert your frozen vial and wait. Audible and visual indicators allow you to track thaw progress. At thaw completion, the vial is gently raised for easy removal and downstream processing. Ideal for cell thawing, or thawing of other biospecimens.
IOPQ packet for ThawSTAR™ is available.

ThawStar™ (#BCS-600)
ThawStar™ (#BCS-601)

GermDecon

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Wide disinfectant for surfaces and instruments, including centrifuges, pipettes etc., for prevention of cross-contamination or infection in laboratories working with biological samples

  • Active against many gram negative and gram positive bacteria, yeast and fungi
  • Non-corrosive, non-carcinogen
  • Easily sprayed on all surfaces without leaving any traces
34207 GermDecon

Mycodecon

Highly effective disinfectant against mycoplasmas for decontamination of all lab surfaces and equipment, including water baths, incubators, liquid nitrogen containers etc.

  • Not only active against mycoplasma but also against bacteria, virus and fungi
  • Non-corrosive, non-carcinogen
  • Easily sprayed on all surfaces without leaving any traces
34206 MycoDecon

DNADecon

Removal of DNA is very important especially on PCR work places to avoid cross-contamination between samples leading to inaccurate data. DNADecon completely destroys and removes DNA and RNA molecules from any surface making it ideal for decontamination prior to PCR reactions. It can be used for decontamination of all surfaces and equipment like electrophoresis chambers, pipettes, reaction tubes etc..

  • Ready-to-use, non-alkaline and non-carcinogenic
  • Complete removal of DNA and RNA
  • Easily sprayed on all surfaces without leaving any traces
39810 DNADecon

Antibiotics for mycoplasma removal

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Mycorase solution (50x)

  • Antibiotica mixture developed for safe eradication
    of mycoplasma contamination in cell culture
  • Broad range of action
  • No effect on cell proliferation
  • Permanent cure for most cell types

Ciprofloxacin hydrochloride

  • Fluoroquinolone antibiotic inhibiting bacterial nucleic acid synthesis
  • Broad spectrum antibiotic targeting a wide variety of gram positive and
    gram negative bacteria
  • No cytotoxic effects at the recommended concentration of ca. 1 µg/ml 

Minocyclin hydrochloride

  • Bacteriostatic tetracycline derivative inhibiting protein sysnthesis
  • Active against gram positive, gram negative bacteria, mycobacteria
    & many mycoplasma strains
  • No cytotoxic effects at min. inhibitory concentration (0.06 - 1 μg/ml)
  • Inhibitor of tumor growth, angiogenesis & metallo proteinases
47987 Mycorase solution
47977 Ciprofloxacin hydrochloride
47978 Minocyclin hydrochloride

SERVA BlueThermo H/HC

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The instruments deliver highest temperature accuracy due to a 10-point-calibration (+/- 0.1°C), fastest temperature control and even temperature distribution. The stable construction as well as the latest technology guarantees reliability.
The smart touch control panel for different operation modes is perfectly adapted to laboratory setups. Use up to 9 programs with 30 program steps in total. Adjustable functions are timer, interval shaking, short mix and shaking frequencies. Surfaces of housing and touch panel are easy to clean.

Units will be delivered without thermoblock. Blocks have to be ordered separately.
More than 30 exchangeable blocks are available. Please inquire for a 2-block thermoshaker or a suitable block for your application.

  • Stable metal housing for high reliability
  • Precise temperature control by 10-point-calibration (+/- 0.1 °C) with large temperature range
  • 9 programs
  • Flexible with over 30 exchangeable blocks
  • Unique touch control panel
  • Large temperature range
  • Smart design - made in Germany
SERVA BlueThermo H
SERVA BlueThermo HC

SERVA BlueCell Aspiration System

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The SERVA BlueCell aspiration system is a cell culture aspiration device with autoclavable 4 l bottle. The housing is made of easy-care, wear-resistant and specially hard anodized aluminium with a powerful integrated membrane vacuum pump, vacuum controller and mounted safety bottle holder as a compact and space saving unit.
The membrane vacuum pump is noise reduced and perfectly adapted to cell culture lab requirements. It is integrated in the housing and gently aspirates 25 l liquid per minute. By default, a pasteur pipette can be slipped on, but a variety of suction adaptors can be ordered. The fast-lock clutches, integrated to the 4 l polypropylene bottle, ensures an easy removal for cleaning. The safety filter prevents leaking of liquids.

The SERVA BlueCell FlowControl acts as multi-user system and is extendable by connecting more bottles, handles or complete collection units. The maximum per single pump is
4 bottles with single handle or 2 bottles with double handles. Additionally for SERVA BlueCell FlowControl, suction start / stop is regulated by turning the swivel of the handle. By turning the swivel, the suction rate is continuously adjustable. If the system is closed, the pump shuts down at reaching the max. vacuum. If the vacuum is reduced during the aspiration, the pump turns on to reach the max. vacuum again.

  • Stable aluminium housing
  • Integrated, noise-reduced vacuum pump
  • Quickly aspiration of liquids
  • Autoclavable 4 l bottle with fast-lock clutches and integrated safety filters Includes handle for flow control

Additional features for SERVA BlueCell FlowControl:

  • Multi-user system
  • Handle-regulated automatic start / stop function
SERVA BlueCell Flow Control

SERVA BlueCell Basic Aspiration System

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The unit is ready to use immediately. The small and low-noise membrane vacuum pump aspirates 8 l liquid per minute.
A handle with flow control (cat. no. BC-HFC) can be attached and connected with different suction system devices.
The fast-lock clutches, integrated to the 4 l polypropylene bottle, ensures an easy removal for cleaning. The safety filter prevents leaking of liquids.

  • Basic aspiration system
  • External, noise-reduced vacuum pump
  • Quick aspiration of liquids
  • Autoclavable 4 l bottle with fast-lock clutches
  • Integrated safety filters
  • Handle for flow control can be attached
SERVA BlueCell Basic
Handle with Flow Control

SERVA BlueSpin

Benchtop Microcentrifuges

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BlueSpin Mini Microcentrifuge
The BlueSpin Mini is a benchtop microcentrifuge for all kinds of sample preparations and molecular biology experiments such as cell-down, phenol extraction, simple spin-down, etc. The BlueSpin Mini is a compact and quiet instrument. The centrifuge is operated easily and the digital LED displays time and speed. The BlueSpin Mini speed can be adjusted up to 13,500 rpm. The unit has a small footprint and a secure stand.

BlueSpin Cryo Microcentrifuge
The BlueSpin Cryo is a refrigerated compact benchtop microcentrifuge for all kinds of molecular biology experiments such as ethanol precipitation, phenol extraction, nucleic acid preparation, cell-down and spin-down of other temperature sensitive reaction mixtures. The BlueSpin Cryo is a compact and quiet instrument. The centrifuge is operated easily and the digital LED displays time, speed and temperature. The temperature can be set from -20 °C to +40 °C.

TN BlueSpin
SERVA BlueSpin Microcentrifuges

Cyanase™ Nuclease:
Your alternative for Benzonase®

For fast and efficient removal of nucleic acid contamination during protein purification

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Cyanase™ Nuclease
Cyanase is a cloned highly active non-Serratia based non-specific endonuclease that degrades single and double stranded DNA and RNA in as little as 1 minute.
• Fastest Nuclease on the market
• Broad pH range
• Active in higher salt concentrations (up to 100 mM NaCl)
• Unaffected by lysozyme, detergents or urea, DTT
• Easily inactivated and removed
• Unsurpassed stability, can be stored up to 1 year at room temperature

Cyanase™ Inactivation Resin
Highly specific Cyanase inhibitor protein coupled to Sepharose Fast Flow resin creating a novel method for inactivating and removing the Cyanase enzyme.
No more worries about downstream contamination with nucleases or difficult removal processes which may compromise product integrity.
• Removal of Cyanase Nuclease simple and easy in as little as 20 min
• No optimization needed
• Active over a wide range of conditions
• No interactions with other proteins or targets
• Extremely tight interaction between Cyanase and resin

Benzonase = trademark of Merck KGaA, Cyanase = trademark of RiboSolutions, Inc.

18542 Cyanase™ Nuclease
18543 Cyanase™ Inactivation Resin

Salt Active Nuclease

The only endonuclease with an optimum activity in 0.5 M NaCl and significant activity at low temperatures

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Salt Active Nuclease is a highly active non-specific endonuclease from a marine bacterium that cleaves both DNA and RNA.
• Works well in traditional protein buffer systems
• Optimum activity at high salt concentration
(0.5 M NaCl) – no other nuclease works at this salt concentration
• Active at low temperatures (20 % at 6 ºC)
• Broad pH range
• Temperature stable
• Inactivated by EDTA

18541 Salt Active Nuclease

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ICPL™ - Coupled Immunoprecipitation
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The New SERVA Catalog 2015/16:

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• Biochemicals A-Z

• Sample Preparation

• Electrophoresis

• Laboratory Equipmeng

• Collagenase & Neutral Protease

• Life Sciences

• Enzymology

• Microscopy

• Ion Exchange Media

• Pharmacopoeia


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- Nucleic Acid Electrophoresis

- 2D Electrophoresis (PDF)

- SDS PAGE (PDF)

- Isoelectric Focusing (PDF)

- Native PAGE (PDF)


New Application Note:
ICPL™ - Coupled Immunoprecipitation
(ICPL-IP)

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ImmunoPrecipitation (IP) is widely used as a method to selectively isolate protein complexes from primary tissues. However, due to lack of specificity and selectivity of most antibodies and unspecific binding of the carrier beads, the method can produce false positives. The ICPL approach, employing stable isotope labelling and mass spectrometry, can discriminate true positive from false positive IP complexes.


SERVA ICPL™ Quadruplex Plus Kit 39233
Application Note: ICPL-IP

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