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AEBSF-HClresearch grade

(Aminoethyl)-benzene sulfonyl fluoride hydrochloride)
C8H10FNO2S·HCl • Mr 239.7 • CAS [30827-99-7]

Irreversible inhibitor of thrombin and other serine proteases (e.g. chymotrypsin, kallikrein, plasmin, proteinase K, trypsin). Inhibits by acylation of the active site of the enzyme. AEBSF is water-soluble and much less toxic than PMSF and DFP. Aqueous solutions are stable between pH 5 - 6; limited stability above pH 7.5.

Assay (HPLC)
min. 98.0 %


References:
  1. Walsmann, P. et al. (1972) Acta biol. med. germ. 28, 577-585
  2. Marwardt, F. et al. (1973) Thrombosis Res. 2, 343-348
  3. Taylor, J.A. et al. (1995) Immunology 86, 629-635
DANGER
Hazard Statements H314
Precautions P264 - P280
Reaction P301 +P330 +P331 - P303 +P361 +P353 - P304 +P340 - P305 +P351 +P338

GGVSE/ADR: 8 II UN3261 • IATA: 8 II UN3261 • WGK: 1 • HS: 29214900
Storage Temperature: +2 °C to +8 °C

Cat.No.
Size
EUR
12745.03
1 g
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H314

Deutsch:

Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

English:

Causes severe skin burns and eye damage.

Français:

Provoque des brûlures de la peau et des lésions oculaires graves.

Italiano:

Provoca gravi ustioni cutanee e gravi lesioni oculari.

Español:

Provoca quemaduras graves en la piel y lesiones oculares graves.

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P264

Deutsch:

Nach Gebrauch … gründlich waschen.

English:

Wash … thoroughly after handling.

Français:

Se laver … soigneusement après manipulation.

Italiano:

Lavare accuratamente … dopo l’uso.

Español:

Lavarse … concienzudamente tras la manipulación.

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P280

Deutsch:

Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz tragen.

English:

Wear protective gloves/protective clothing/eye protection/face protection.

Français:

Porter des gants de protection/des vêtements de protection/un équipement de protection des yeux/du visage.

Italiano:

Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.

Español:

Llevar guantes/prendas/gafas/máscara de protección.

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P301 +P330 +P331

Deutsch:

BEI VERSCHLUCKEN: Mund ausspülen. KEIN Erbrechen herbeiführen.

English:

IF SWALLOWED: rinse mouth. Do NOT induce vomiting.

Français:

EN CAS D’INGESTION: rincer la bouche. NE PAS faire vomir.

Italiano:

IN CASO DI INGESTIONE: sciacquare la bocca. NON provocare il vomito.

Español:

EN CASO DE INGESTIÓN: Enjuagarse la boca. NO provocar el vómito.

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P303 +P361 +P353

Deutsch:

BEI KONTAKT MIT DER HAUT (oder dem Haar): Alle beschmutzten, getränkten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen/duschen.

English:

IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.

Français:

EN CAS DE CONTACT AVEC LA PEAU (ou les cheveux): enlever immédiatement les vêtements contaminés. Rincer la peau à l’eau/se doucher.

Italiano:

IN CASO DI CONTATTO CON LA PELLE (o con i capelli): togliersi di dosso immediatamente tutti gli indumenti contaminati. Sciacquare la pelle/fare una doccia.

Español:

EN CASO DE CONTACTO CON LA PIEL (o el pelo): Quitarse inmediatamente las prendas contaminadas. Aclararse la piel con agua o ducharse.

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P304 +P340

Deutsch:

BEI EINATMEN: An die frische Luft bringen und in einer Position ruhigstellen, die das Atmen erleichtert.

English:

IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

Français:

EN CAS D’INHALATION: transporter la victime à l’extérieur et la maintenir au repos dans une position où elle peut confortablement respirer.

Italiano:

IN CASO DI INALAZIONE: trasportare l'infortunato all’aria aperta e mantenerlo a riposo in posizione che favorisca la respirazione.

Español:

EN CASO DE INHALACIÓN: Transportar a la víctima al exterior y mantenerla en reposo en una posición confortable para respirar.

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P305 +P351 +P338

Deutsch:

BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

English:

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Français:

EN CAS DE CONTACT AVEC LES YEUX: rincer avec précaution à l’eau pendant plusieurs minutes. Enlever les lentilles de contact si la victime en porte et si elles peuvent être facilement enlevées. Continuer à rincer

Italiano:

IN CASO DI CONTATTO CON GLI OCCHI: sciacquare accuratamente per parecchi minuti. Togliere le eventuali lenti a contatto se è agevole farlo. Continuare a sciacquare.

Español:

EN CASO DE CONTACTO CON LOS OJOS: Aclarar cuidadosamente con agua durante varios minutos. Quitar las lentes de contacto, si lleva y resulta fácil. Seguir aclarando.