Cytochalasin B

C29H37NO5Mr 479.6CAS [14930-96-2]

Cytochalasin B is a metabolite of the fungus Drechslera dematoidea which binds to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits.
Cytochalasin B is a reversible inhibitor of cell motion (1), inhibits phagocytosis (2), induces polyploidy (3) and induces nuclear extrusion (4, 5). It binds to the glucose transporter and inhibits monosaccharide transport across the plasma membrane.

Assay (HPLC)
Assay (TLC)

> 98.0 %
> 98.0 %


References:
  1. Becker, E. et al. (1972) J. Immunol. 108, 396-401
  2. Davis, A. et al. (1971) Proc. Soc. Exp. Biol. Med. 137, 161- 7
  3. Hoehn, H. et al. (1972) Fed. Proc. 31, A 607-8
  4. Krishan, A. (1972) J. Cell Biol. 54, 657- 62
  5. Prescott, D. (1972) Exp. Cell Res. 71, 480-3
DANGER
Hazard Statements H300 - H310 - H330 - H361d
Precautions P201 - P260 - P281
Reaction P301 +P310 - P302 +P350 - P304 +P340

Repr. 2GGVSE/ADR: 6.1 II UN2811IATA: 6.1 II UN2811EINECS: 239-000-2WGK: 2HS: 29339980
Storage Temperature: +2 °C to +8 °C

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H300

Deutsch:

Lebensgefahr bei Verschlucken.

English:

Fatal if swallowed.

Français:

Mortel en cas d'ingestion.

Italiano:

Letale se ingerito.

Español:

Mortal en caso de ingestión.

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H310

Deutsch:

Lebensgefahr bei Hautkontakt.

English:

Fatal in contact with skin.

Français:

Mortel par contact cutané.

Italiano:

Letale per contatto con la pelle.

Español:

Mortal en contacto con la piel.

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H330

Deutsch:

Lebensgefahr bei Einatmen.

English:

Fatal if inhaled.

Français:

Mortel par inhalation.

Italiano:

Letale se inalato.

Español:

Mortal en caso de inhalación.

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H361d

Deutsch:

Kann vermutlich das Kind im Mutterleib schädigen.

English:

Suspected of damaging the unborn child.

Français:

Susceptible de nuire au foetus.

Italiano:

Sospettato di nuocere al feto.

Español:

Se sospecha que daña al feto.

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P201

Deutsch:

Vor Gebrauch besondere Anweisungen einholen.

English:

Obtain special instructions before use.

Français:

Se procurer les instructions avant utilisation.

Italiano:

Procurarsi istruzioni specifiche prima dell’uso.

Español:

Pedir instrucciones especiales antes del uso.

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P260

Deutsch:

Staub/Rauch/Gas/Nebel/Dampf/Aerosol nicht einatmen.

English:

Do not breathe dust/fume/gas/mist/vapours/spray.

Français:

Ne pas respirer les poussières/fumées/gaz/brouillards/vapeurs/aérosols.

Italiano:

Non respirare la polvere/i fumi/i gas/la nebbia/i vapori/gli aerosol.

Español:

No respirar el polvo/el humo/el gas/la niebla/los vapores/el aerosol.

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P281

Deutsch:

Vorgeschriebene persönliche Schutzausrüstung verwenden.

English:

Use personal protective equipment as required.

Français:

Utiliser l’équipement de protection individuel requis.

Italiano:

Utilizzare il dispositivo di protezione individuale richiesto.

Español:

Utilizar el equipo de protección individual obligatorio.

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P301 +P310

Deutsch:

BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM oder Arzt anrufen.

English:

IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Français:

EN CAS D’INGESTION: appeler immédiatement un CENTRE ANTIPOISON ou un médecin.

Italiano:

IN CASO DI INGESTIONE: contattare immediatamente un CENTRO ANTIVELENI o un medico

Español:

EN CASO DE INGESTIÓN: Llamar inmediatamente a un CENTRO DE INFORMACIÓN TOXICOLÓGICA o a un médico.

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P302 +P350

Deutsch:

BEI KONTAKT MIT DER HAUT: Behutsam mit viel Wasser und Seife waschen.

English:

IF ON SKIN: Gently wash with plenty of soap and water.

Français:

EN CAS DE CONTACT AVEC LA PEAU: laver avec précaution et abondamment à l’eau et au savon.

Italiano:

IN CASO DI CONTATTO CON LA PELLE: lavare delicatamente e abbondantemente con acqua e sapone.

Español:

EN CASO DE CONTACTO CON LA PIEL: Lavar suavemente con agua y jabón abundantes.

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P304 +P340

Deutsch:

BEI EINATMEN: An die frische Luft bringen und in einer Position ruhigstellen, die das Atmen erleichtert.

English:

IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

Français:

EN CAS D’INHALATION: transporter la victime à l’extérieur et la maintenir au repos dans une position où elle peut confortablement respirer.

Italiano:

IN CASO DI INALAZIONE: trasportare l'infortunato all’aria aperta e mantenerlo a riposo in posizione che favorisca la respirazione.

Español:

EN CASO DE INHALACIÓN: Transportar a la víctima al exterior y mantenerla en reposo en una posición confortable para respirar.