GDN

(Synthetic drop-in substitute for digitonin, Glyco-diosgenin)
C56H92O25 Mr 1165,31 CAS [1402423-29-3]

CMC (H2O, 25 °C) ca. 18 µM

Synthetic, non-toxic, cost-effective substitute for digitonin ideal for the solubilization, purification, and Cryo-EM studies of membrane proteins.
It contains a steroid-based hydrophobic group linked to a di-maltose head group.
The molecular weight is similar to digitonin, but CMC is much smaller. No batch-to-batch variability due to synthetic nature. Contains no harmful toxic byproducts typically found in digitonin, such as digitoxin, digoxin, and other cardiac and steroidal glycosides.
Because it is a milder detergent compared to DDM, it is effective in maintaining membrane proteins in a functional state.



Purity (HPLC)
Solubility in H2O (20 °C)
≥ 98 %
≥ 10 %


References:
  1. Thomas, J. A. & Tate, C. G. (2014) J. Mol. Biol. 426(24), 4139-4154
WARNING
Hazard Statements H335
Precautions P261 - P271
Reaction P304 +P340 - P312
Storage P405

HS: 34029010


Cat.No.
Size
EUR
60109.01
500 mg
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60109.02
1 g
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60109.03
5 g
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60109.04
25 g
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In detail you will find the following new products in catalog 2022:

New glycosidases such as Endo F3, Endo S and Sialidase
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New protein standards, e.g. SERVA Triple Color Protein Standard I    and the SERVA Fluo-610 Protein Standard I, pre-stained for direct fluorescence detection
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H335

Deutsch:

Kann die Atemwege reizen.

English:

May cause respiratory irritation.

Français:

Peut irriter les voies respiratoires.

Italiano:

Può irritare le vie respiratorie.

Español:

Puede irritar las vías respiratorias.

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P261

Deutsch:

Einatmen von Staub/Rauch/Gas/Nebel/Dampf/Aerosol vermeiden.

English:

Avoid breathing dust/fume/gas/mist/vapours/spray.

Français:

Éviter de respirer les poussières/fumées/gaz/brouillards/vapeurs/aérosols.

Italiano:

Evitare di respirare la polvere/i fumi/i gas/la nebbia/i vapori/gli aerosol.

Español:

Evitar respirar el polvo/el humo/el gas/la niebla/los vapores/el aerosol.

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P271

Deutsch:

Nur im Freien oder in gut belüfteten Räumen verwenden.

English:

Use only outdoors or in a well-ventilated area.

Français:

Utiliser seulement en plein air ou dans un endroit bien ventilé.

Italiano:

Utilizzare soltanto all’aperto o in luogo ben ventilato.

Español:

Utilizar únicamente en exteriores o en un lugar bien ventilado.

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P304 +P340

Deutsch:

BEI EINATMEN: An die frische Luft bringen und in einer Position ruhigstellen, die das Atmen erleichtert.

English:

IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

Français:

EN CAS D’INHALATION: transporter la victime à l’extérieur et la maintenir au repos dans une position où elle peut confortablement respirer.

Italiano:

IN CASO DI INALAZIONE: trasportare l'infortunato all’aria aperta e mantenerlo a riposo in posizione che favorisca la respirazione.

Español:

EN CASO DE INHALACIÓN: Transportar a la víctima al exterior y mantenerla en reposo en una posición confortable para respirar.

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P312

Deutsch:

Bei Unwohlsein GIFTINFORMATIONSZENTRUM oder Arzt anrufen.

English:

Call a POISON CENTER or doctor/physician if you feel unwell.

Français:

Appeler un CENTRE ANTIPOISON ou un médecin en cas de malaise.

Italiano:

In caso di malessere, contattare un CENTRO ANTIVELENI o un medico.

Español:

Llamar a un CENTRO DE INFORMACION TOXICOLOGICA o a un médico en caso de malestar.

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P405

Deutsch:

Unter Verschluss aufbewahren.

English:

Store locked up.

Français:

Garder sous clef.

Italiano:

Conservare sotto chiave.

Español:

Guardar bajo llave.