Lipids are commonly used by researchers to stabilize membrane proteins. However, the common challenge with working with lipids is their high cost and lack of solubility in water.

Anatrace^® scientists answered the challenge and developed innovative Anatrace Fos-Choline^® detergents.
The Fos-Choline detergents have been successfully used in membrane protein studies by NMR. Fos-Cholines employ charged amine and phosphate groups in combination with an alkyl chain to produce a zwitterionic surfactant. This unique architecture is water-soluble and capable of both stabilizing and keeping membrane proteins soluble in aqueous solutions. This surfactant also produces micelles and is able to extract membrane proteins from cellular membranes.

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