Min. 590 U/mg gentamycin base/g. Aminoglycoside antibiotic complex from Micromonospora
purpurea. Consists of closely related compounds: gentamycin C1,
C1a, C2, C2a and C2b. Inhibits
bacterial protein synthesis by binding to the ribosomal 30S subunit and
causing misreading of mRNA (in a similar way as streptomycin). Broad
spectrum antibiotic which inhibits growth of many gram positive and gram
negative bacteria including strains which are resistant to chloramphenicol,
kanamycin or tetracycline. Frequently used in cell culture, often in
combination with amphotericin B, nystatin or penicillin G (1,3).
Watts, J.W. & King, J.M. (1973) Planta 113, 271-7
Cox, D. et al. (1977) in: Sammes, P.G. (ed.) Topics in antibiotics chemistry Vol. I Chichester: Horwood, pp. 1-90
Eichholtz, D.A. et al. (1979) Plant Physiol. 63, Abstr. 753
Lancini, G. & Parenti, F. (1982) Antibiotics; Springer, New York
Nakamura, T. et al. (1991) J. Biol. Chem. 266, 19432-7
Stubbs, A.C. et al. (2001) Nature Medicine 7, 625-9
Manevich, Y. et al. (2002) PNAS 99, 11599-604
Richard, J.P. et al. (2005) J. Biol. Chem. 280, 15300-6
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