Neutral Protease NB GMP Grade from Clostridium histolyticum
Mr ca. 34 000 • CAS [9001-92-7]
Contains chromatographically purified neutral protease. Vial contains
not less than 100 DMC U neutral protease. Neutral protease activity
(DMC): ≥ 0.50 U/mg Largely free of collagenase PZ activity. Microbiological
examination: Total aerobic microbial count (TAMC), Total combined yeast/moulds
count (TYMC), Absence of Clostridia, Abnormal toxicity
(General-Safety-Test; Ph. Eur.). Manufactured according to international
cGMP guidelines. Metalloprotease suitable for tissue dissociation
applications and cell detachment. Cell isolation with Neutral Protease NB GMP
Grade in combination with purified Collagenase NB 1 GMP Grade (cat. no. 17452)
as well as Collagenase NB 6 GMP Grade (cat. no. 17458) for applications which
have to meet cGMP requirements like tissue engineering and transplantation
into humans.
Unit definition: 1 DMC Unit catalyzes the cleavage of 1 µmole peptide
bond from dimethylcasein per minute at 25 °C, pH 7.0, expressed in terms of
newly formed terminal amino groups, determined with TNBS.
References:
Lin, Y.-C. et al. (1969) J. Biol. Chem. 244, 789-93.
For his work on a new selective method to isolate and analyze phospho- and glycoproteins Fabio Polato from the University of Innsbruck received the SERVA Young Scientists Award 2010 during the "17. Arbeitstagung Mikromethoden in der Proteinchemie" (21 to 23 June 2010, Martinsried, Germany). Congratulations!
(in front: Fabio Polato (Universität Innsbruck) and Barbara Müller (SERVA, Heidelberg), background left: Helmut E. Meyer (Ruhr-Universität Bochum), right: Roland Kellner (MERCK, Darmstadt)
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R 36/37/38
Deutsch:
Reizt die Augen, die Atmungsorgane und die Haut.
English:
Irritating to eyes, respiratory system and skin.
Français:
Irritant pour les yeux, les voies respiratoires et la peau.
Italiano:
Irritante per gli occhi, le vie respiratorie e la pelle.
Español:
Irrita los ojos, la piel y las vías respiratorias.
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