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Thapsigargin

research grade
C34H50O12Mr 650.8CAS [67526-95-8]

Tumor-promoting sesquiterpene Lactone. Induces the release of intracellular calcium stores by inhibition of the ER/microsomal Ca2+ ATPase.

Assay (HPLC)
Assay (TLC)
min. 95 %
homogeneous


References:
  1. Wong, W.E. et al. (1993) Biochem. 289, 71-9
  2. Low, A.M. et al. (1993) Eur. J. Pharmacol. 230, 53-62
  3. Charlesworth, A. & Rozengurt, E. (1994) J. Biol. Chem. 269, 32528-35
  4. Foskett, J.K. & Wong, D.C. (1994) J. Biol. Chem. 269, 31525-32
  5. Furuya, Y. et al. (1994) Cancer Res. 54, 6167-75
  6. Palmer, F.P. et al. (1994) Biochim. Biophys. Acta 1215, 190-7
WARNING
Hazard Statements H302 - H332 - H341
Precautions P261 - P281
Reaction P301 +P312 - P304 +P340 - P330
Storage P501

HS: 29419000
Storage Temperature: -15 °C to -25 °C


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Thursday, May 24, 2012

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H302

Deutsch:

Gesundheitsschädlich bei Verschlucken.

English:

Harmful if swallowed.

Français:

Nocif en cas d'ingestion.

Italiano:

Nocivo se ingerito.

Español:

Nocivo en caso de ingestión.

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H332

Deutsch:

Gesundheitsschädlich bei Einatmen.

English:

Harmful if inhaled.

Français:

Nocif par inhalation.

Italiano:

Nocivo se inalato.

Español:

Nocivo en caso de inhalación.

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H341

Deutsch:

Kann vermutlich genetische Defekte verursachen <Expositionsweg angeben, sofern schlüssig belegt ist, dass diese Gefahr bei keinem anderen Expositionsweg besteht>.

English:

Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Français:

Susceptible d'induire des anomalies génétiques <indiquer la voie d'exposition s'il est formellement prouvé qu'aucune autre voie d'exposition ne conduit au même danger>.

Italiano:

Sospettato di provocare alterazioni genetiche <indicare la via di esposizione se è accertato che nessun'altra via di esposizione comporta il medesimo pericolo>.

Español:

Se sospecha que provoca defectos genéticos <Indíquese la vía de exposición si se ha demostrado concluyentemente que el peligro no se produce por ninguna otra vía >.

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P261

Deutsch:

Einatmen von Staub/Rauch/Gas/Nebel/Dampf/Aerosol vermeiden.

English:

Avoid breathing dust/fume/gas/mist/vapours/spray.

Français:

Éviter de respirer les poussières/fumées/gaz/brouillards/vapeurs/aérosols.

Italiano:

Evitare di respirare la polvere/i fumi/i gas/la nebbia/i vapori/gli aerosol.

Español:

Evitar respirar el polvo/el humo/el gas/la niebla/los vapores/el aerosol.

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P281

Deutsch:

Vorgeschriebene persönliche Schutzausrüstung verwenden.

English:

Use personal protective equipment as required.

Français:

Utiliser l’équipement de protection individuel requis.

Italiano:

Utilizzare il dispositivo di protezione individuale richiesto.

Español:

Utilizar el equipo de protección individual obligatorio.

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P301 +P312

Deutsch:

BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM oder Arzt anrufen.

English:

IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.

Français:

EN CAS D’INGESTION: appeler un CENTRE ANTIPOISON ou un médecin en cas de malaise.

Italiano:

IN CASO DI INGESTIONE accompagnata da malessere: contattare un CENTRO ANTIVELENI o un medico.

Español:

EN CASO DE INGESTIÓN: Llamar a un CENTRO DE INFORMACIÓN TOXICOLÓGICA o a un médico si se encuentra mal.

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P304 +P340

Deutsch:

BEI EINATMEN: An die frische Luft bringen und in einer Position ruhigstellen, die das Atmen erleichtert.

English:

IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

Français:

EN CAS D’INHALATION: transporter la victime à l’extérieur et la maintenir au repos dans une position où elle peut confortablement respirer.

Italiano:

IN CASO DI INALAZIONE: trasportare l'infortunato all’aria aperta e mantenerlo a riposo in posizione che favorisca la respirazione.

Español:

EN CASO DE INHALACIÓN: Transportar a la víctima al exterior y mantenerla en reposo en una posición confortable para respirar.

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P330

Deutsch:

Mund ausspülen.

English:

Rinse mouth.

Français:

Rincer la bouche.

Italiano:

Sciacquare la bocca.

Español:

Enjuagarse la boca.

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