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Hygromycin B

solution
C20H37N3O13Mr 527.53CAS [31282-04-9]

Aminoglycoside antibiotic that inhibits growth of procaryotic micro-organisms (bacteria), eukaryotic microorganisms (yeasts) and mammalian cells.
Inhibits protein synthesis at translocation step; causes misreading of mRNA. A gene from E. coli encoding resistance to hygromycin B can be isolated and cloned by recombinant DNA technology. It is useful for the identification or selection of recombinant clones in various cell types.
500 000 U correspond to approx. 1 ml.

Assay (HPLC)
Microbiological activity
min. 80 %
min. 400 000 U/ml


References:
  1. Gonzales, A. et al. (1978) Biochim. Biophys. Acta 512, 459
  2. Pardo, J.M. et al. (1985) J. Gen. Microbiol. 131, 1289
  3. Kuhstoss, S. & Rao, R.N. (1983) Gene 26, 295
  4. Ma, H. et al. (1992) Gene 117, 161
DANGER
Hazard Statements H300 - H310 - H315 - H318 - H330 - H335
Precautions P260 - P280
Reaction P301 +P312 - P302 +P352 - P304 +P340 - P305 +P351 +P338

GGVSE/ADR: 6.1 I UN2810IATA: 6.1 I UN2810WGK: 2HS: 29419000
Storage Temperature: +2 °C to +8 °C


Cat.No. Size EUR
25966.01 500,000 U inquire*  
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H300

Deutsch:

Lebensgefahr bei Verschlucken.

English:

Fatal if swallowed.

Français:

Mortel en cas d'ingestion.

Italiano:

Letale se ingerito.

Español:

Mortal en caso de ingestión.

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H310

Deutsch:

Lebensgefahr bei Hautkontakt.

English:

Fatal in contact with skin.

Français:

Mortel par contact cutané.

Italiano:

Letale per contatto con la pelle.

Español:

Mortal en contacto con la piel.

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H315

Deutsch:

Verursacht Hautreizungen.

English:

Causes skin irritation.

Français:

Provoque une irritation cutanée.

Italiano:

Provoca irritazione cutanea.

Español:

Provoca irritación cutánea.

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H318

Deutsch:

Verursacht schwere Augenschäden.

English:

Causes serious eye damage.

Français:

Provoque des lésions oculaires graves.

Italiano:

Provoca gravi lesioni oculari.

Español:

Provoca lesiones oculares graves.

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H330

Deutsch:

Lebensgefahr bei Einatmen.

English:

Fatal if inhaled.

Français:

Mortel par inhalation.

Italiano:

Letale se inalato.

Español:

Mortal en caso de inhalación.

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H335

Deutsch:

Kann die Atemwege reizen.

English:

May cause respiratory irritation.

Français:

Peut irriter les voies respiratoires.

Italiano:

Può irritare le vie respiratorie.

Español:

Puede irritar las vías respiratorias.

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P260

Deutsch:

Staub/Rauch/Gas/Nebel/Dampf/Aerosol nicht einatmen.

English:

Do not breathe dust/fume/gas/mist/vapours/spray.

Français:

Ne pas respirer les poussières/fumées/gaz/brouillards/vapeurs/aérosols.

Italiano:

Non respirare la polvere/i fumi/i gas/la nebbia/i vapori/gli aerosol.

Español:

No respirar el polvo/el humo/el gas/la niebla/los vapores/el aerosol.

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P280

Deutsch:

Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz tragen.

English:

Wear protective gloves/protective clothing/eye protection/face protection.

Français:

Porter des gants de protection/des vêtements de protection/un équipement de protection des yeux/du visage.

Italiano:

Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.

Español:

Llevar guantes/prendas/gafas/máscara de protección.

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P301 +P312

Deutsch:

BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM oder Arzt anrufen.

English:

IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.

Français:

EN CAS D’INGESTION: appeler un CENTRE ANTIPOISON ou un médecin en cas de malaise.

Italiano:

IN CASO DI INGESTIONE accompagnata da malessere: contattare un CENTRO ANTIVELENI o un medico.

Español:

EN CASO DE INGESTIÓN: Llamar a un CENTRO DE INFORMACIÓN TOXICOLÓGICA o a un médico si se encuentra mal.

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P302 +P352

Deutsch:

BEI KONTAKT MIT DER HAUT: Mit viel Wasser und Seife waschen.

English:

IF ON SKIN: Wash with plenty of soap and water.

Français:

EN CAS DE CONTACT AVEC LA PEAU: laver abondamment à l’eau et au savon.

Italiano:

IN CASO DI CONTATTO CON LA PELLE: lavare abbondantemente con acqua e sapone.

Español:

EN CASO DE CONTACTO CON LA PIEL: Lavar con agua y jabón abundantes.

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P304 +P340

Deutsch:

BEI EINATMEN: An die frische Luft bringen und in einer Position ruhigstellen, die das Atmen erleichtert.

English:

IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

Français:

EN CAS D’INHALATION: transporter la victime à l’extérieur et la maintenir au repos dans une position où elle peut confortablement respirer.

Italiano:

IN CASO DI INALAZIONE: trasportare l'infortunato all’aria aperta e mantenerlo a riposo in posizione che favorisca la respirazione.

Español:

EN CASO DE INHALACIÓN: Transportar a la víctima al exterior y mantenerla en reposo en una posición confortable para respirar.

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P305 +P351 +P338

Deutsch:

BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

English:

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Français:

EN CAS DE CONTACT AVEC LES YEUX: rincer avec précaution à l’eau pendant plusieurs minutes. Enlever les lentilles de contact si la victime en porte et si elles peuvent être facilement enlevées. Continuer à rincer

Italiano:

IN CASO DI CONTATTO CON GLI OCCHI: sciacquare accuratamente per parecchi minuti. Togliere le eventuali lenti a contatto se è agevole farlo. Continuare a sciacquare.

Español:

EN CASO DE CONTACTO CON LOS OJOS: Aclarar cuidadosamente con agua durante varios minutos. Quitar las lentes de contacto, si lleva y resulta fácil. Seguir aclarando.

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