(Actinospectacin; M 141)
C14H24N2O7·2HCl·5H2O
• Mr
495.4
• CAS [22189-32-8]
Cell culture tested. Water-soluble aminoglycoside antibiotic from Streptomyces
sp. (1,2). Inhibitor of protein synthesis (3). Differs from other
aminoglycoside derivatives in that it is bacteriostatic instead of
bactericidal. Stock solution: 10 mg/ml in distilled water, sterile
filtered. For molecular biology applications standard working concentration
is 100 µg/ml and in cell culture 7.5 – 20 mg/l.
References:
Wagner J. G. et al. (1968) Int. Z. Klin. Pharmakol. Ther. Toxikol. 1,
261 – 85
Wallace, B.J. et al. (1979) Antibiotics 5, 272 – 303
Wallace, P.-C. et al. (1979) in Antibiotics, Vol. V, part I. Mechanism of
Action of Antibacterial Agents, Springer Verlag Berlin
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