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Chymostatin

research grade

([(S)-1-Carboxy-2-phenylethyl]-carbamoyl-α-2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal)
CAS [9076-44-2]

Mixture of 3 components differing in amino acid composition at position X with component A as major form (approx. 70 %):

Component A (C₃₁H₄₁N₇O₆; Mr: 607.7):
Component B (C₃₀H₃₉N₇O₆; Mr: 593.7):
Component C (C₃₁H₄₁N₇O₆; Mr: 607.7):

X = L-Leu
X = L-Val
X = L-Ile

Inhibitor of many proteinases e.g. chymotrypsin, chymotrypsin-like serine proteinases and lysosomal cysteine proteinases e.g. cathepsins B, H, and L (1, 2). Inhibits eosinophil peroxidase release from activated human eosinophils (3). Inhibitor of mammalian protein methylesterase activity (4). Effects on globin hydrolysis by cultured malaria parasites (5). Specific inhibitor of a chymostatin sensitive angiotensin II generating enzyme (6, 7).

References:

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Stein, R.L. & Strimpler, A.M. (1987) Biochemistry 26, 2611-5
Matsunaga, Y. et al. (1994) Arch. Biochem. Biophys. 312, 67-74
Veeraragavan, K. & Gagnon, C. (1987) Biochem. Biophys. Res.Commun. 142, 603-8
Rosenthal, P.J. (1995) Exp. Parasitol. 80, 272-81
Okunishi, H. et al. (1993) Jpn. J. Pharmacol. 62, 207-10
Okamura, T. et al. (1990) J. Cardiovasc. Pharmacol. 15, 353-9