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Tunicamycin from Streptomyces chartreusis
Mr ca. 840 • CAS [11089-65-9]
Mixture of homologuous nucleoside antibiotics. Consists of one residue each of uracil, a C11-aminodeoxy- dialdose (tunicamine), N-acetyl glucosamine and a fatty acid. The various tunicamycins differ from each other in the chain length of their fatty acid component.
Our preparation contains mainly isomers A, B, C, and D whose fatty acid component contain 15, 16, 17, and 18 C-atoms, respectively.
Tunicamycin is active against Gram-positive bacteria, yeast, fungi, and viruses. Inhibits N-linked glycosilation and blocks the formation of N-glycosidic protein carbohydrate linkage; inhibits the first step in the lipid-linked saccharide pathway, i.e. the formation of dolichylpyrophosphoryl-GlcNAc. Soluble in DMF and DMSO.
Protect from light. Keep under argon.
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Assay (HPLC)
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max. 98 %
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References:
- Takatsuki, A. et al. (1971) J. Antibiot. 24, 215
- Tkacz, J.S. & Lampén, O. (1975) Biochem. Biophys. Res. Commun. 65, 248
- Ericson, M. et al. (1977) J. Biol. Chem. 252, 7431
- Takatsuki, A. et al. (1977) Agric. Biol. Chem. 41, 2307-9
- Elbein, A.D. (1981) Trends Biochem. Sci. 6, 219-21
- Elbein, A.D. (1987) Methods Enzymol. 138, 661-709
T+
Highly toxic
R: 26/28 - 33
S: 45
GGVSE/ADR: 6.1 III UN2811 • IATA: 6.1 III UN2811 • WGK: 3L • HS: 29419000
Storage Temperature: +2 °C to +8 °C
| Cat.No. | Size | EUR |  |
|---|---|---|---|
| 37467.01 | 5 mg | inquire* | |
| 37467.02 | 10 mg | inquire* | |
| *Please log in to see your actual prices. | |||
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