Collagenase NB

SERVA Collagenase NB – For gentle and efficient tissue dissociation

Collagenases from Clostridium histolyticum are proteolytic enzymes that are able to cleave peptide bonds in the triple helical collagen molecule of human or animal tissue in situ. For this reason collagenases are widely used for cell isolation applications. SERVA’s Collagenase NB products are particularly suitable for gentle and efficient dissociation of numerous tissue types leading to high yields of viable cells.

SERVA’s portfolio includes Collagenase NB products with different enzymatic activities which are suitable for diverse application fields.
For clinical applications GMP grade Collagenase NB products are available which can be used for isolation of cells, including stem cells, e.g. for regenerative medicine, tissue engineering or cell therapy.
For research and for protocol development SERVA offers several non-GMP grade Collagenases NB products.

SERVA’s comprehensive portfolio for tissue digestion is completed by further products like Neutral Protease NB, Collagenase NB Reference Content, Collagenase NB Reference Identity, and Anti-Collagenase polyclonal antibodies.

All Collagenase NB and Neutral Protease NB products are manufactured by the German pharmaceutical company Nordmark Arzneimittel, which is the world’s largest manufacturer of collagenase. The application of pharmaceutical manufacturing standards guarantees high quality and safety of the products. For customers of GMP products, SERVA provides several documents issued by Nordmark to assist in regulatory affairs.

Detailed information on applications, manufacturing and technical data for our Collagenase NB products can be found on this website. For further information please do not hesitate to contact us at collagenase@serva.de.

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New Application Note:
ICPL™ - Coupled Immunoprecipitation
(ICPL-IP)

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Protein-free Blocking Reagent for Western Blots

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BlueNews: Issue June 2016.pdf
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New Application Note:
ICPL™ - Coupled Immunoprecipitation
(ICPL-IP)

ImmunoPrecipitation (IP) is widely used as a method to selectively isolate protein complexes from primary tissues. However, due to lack of specificity and selectivity of most antibodies and unspecific binding of the carrier beads, the method can produce false positives. The ICPL approach, employing stable isotope labelling and mass spectrometry, can discriminate true positive from false positive IP complexes.

SERVA ICPL™ Quadruplex Plus Kit 39233
Application Note: ICPL-IP
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